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tkanina Tableta Možná overall mutation load and p53 mutations Pedagogika mimozemšťan Tušit

Mutant p53 elicits context-dependent pro-tumorigenic phenotypes | Oncogene
Mutant p53 elicits context-dependent pro-tumorigenic phenotypes | Oncogene

Mutations of the p53 Gene as a Prognostic Factor in Aggressive B-Cell  Lymphoma | NEJM
Mutations of the p53 Gene as a Prognostic Factor in Aggressive B-Cell Lymphoma | NEJM

Implications of driver genes associated with a high tumor mutation burden  identified using next‑generation sequencing on immunotherapy in  hepatocellular carcinoma
Implications of driver genes associated with a high tumor mutation burden identified using next‑generation sequencing on immunotherapy in hepatocellular carcinoma

The p53 network: cellular and systemic DNA damage responses in cancer and  aging: Trends in Genetics
The p53 network: cellular and systemic DNA damage responses in cancer and aging: Trends in Genetics

The function of a heterozygous p53 mutation in a Li-Fraumeni syndrome  patient | PLOS ONE
The function of a heterozygous p53 mutation in a Li-Fraumeni syndrome patient | PLOS ONE

Omics analyses of a somatic Trp53R245W/+ breast cancer model identify  cooperating driver events activating PI3K/AKT/mTOR signaling | PNAS
Omics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling | PNAS

Scientists unveil chemotherapy resistance mechanism related to p53 mutation
Scientists unveil chemotherapy resistance mechanism related to p53 mutation

Implications of driver genes associated with a high tumor mutation burden  identified using next‑generation sequencing on immunotherapy in  hepatocellular carcinoma
Implications of driver genes associated with a high tumor mutation burden identified using next‑generation sequencing on immunotherapy in hepatocellular carcinoma

IJMS | Free Full-Text | Do Mutations Turn p53 into an Oncogene?
IJMS | Free Full-Text | Do Mutations Turn p53 into an Oncogene?

Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune  escape through PHLPP2/AKT/PD-L1 pathway
Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway

The p53 Protein: Mutations, Cancer & Cell Signalling - Assay Genie
The p53 Protein: Mutations, Cancer & Cell Signalling - Assay Genie

Significance of TP53 mutation in bladder cancer disease progression and  drug selection [PeerJ]
Significance of TP53 mutation in bladder cancer disease progression and drug selection [PeerJ]

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational  burden | Genome Medicine | Full Text
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden | Genome Medicine | Full Text

Germline TP53 mutations undergo copy number gain years prior to tumor  diagnosis | Nature Communications
Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis | Nature Communications

Recurrent somatic mutations reveal new insights into consequences of  mutagenic processes in cancer | PLOS Computational Biology
Recurrent somatic mutations reveal new insights into consequences of mutagenic processes in cancer | PLOS Computational Biology

Frontiers | A TP53-Associated Immune Prognostic Signature for the  Prediction of Overall Survival and Therapeutic Responses in Muscle-Invasive  Bladder Cancer
Frontiers | A TP53-Associated Immune Prognostic Signature for the Prediction of Overall Survival and Therapeutic Responses in Muscle-Invasive Bladder Cancer

Gaining insights into relevance across cancers based on mutation features  of TP53 gene - ScienceDirect
Gaining insights into relevance across cancers based on mutation features of TP53 gene - ScienceDirect

An unexpected role for p53 in regulating cancer cell–intrinsic PD-1 by  acetylation | Science Advances
An unexpected role for p53 in regulating cancer cell–intrinsic PD-1 by acetylation | Science Advances

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule  Stabilizers: the Y220X Paradigm | ACS Chemical Biology
Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm | ACS Chemical Biology

p53 Is the Most Frequently Mutated Gene in Cancer, but Can We Target It?
p53 Is the Most Frequently Mutated Gene in Cancer, but Can We Target It?

TP53 mutational landscape of metastatic head and neck cancer reveals  patterns of mutation selection - eBioMedicine
TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection - eBioMedicine

TP53 mutation spectrum in primary colorectal cancers. a Proportion of... |  Download Scientific Diagram
TP53 mutation spectrum in primary colorectal cancers. a Proportion of... | Download Scientific Diagram

LRP1B or TP53 mutations are associated with higher tumor mutational burden  and worse survival in hepatocellular carcinoma
LRP1B or TP53 mutations are associated with higher tumor mutational burden and worse survival in hepatocellular carcinoma

Cancers | Free Full-Text | TP53 Combined Phenotype Score Is Associated with  the Clinical Outcome of TP53-Mutated Myelodysplastic Syndromes
Cancers | Free Full-Text | TP53 Combined Phenotype Score Is Associated with the Clinical Outcome of TP53-Mutated Myelodysplastic Syndromes